Basophil activation test: a reliable biomarker for allergen immunotherapy?
نویسنده
چکیده
منابع مشابه
The usefulness of the basophil activation test in monitoring specific immunotherapy with house dust mite allergens
Introduction In clinical practice, reliable tools for monitoring specific immunotherapy (SIT) are of utmost importance. Aim To assess the usefulness of the basophil activation test (BAT) in monitoring SIT in paediatric patients with allergy to house dust mites (HDM). Material and methods Thirty-one children qualified for SIT with HDM, of whom 21 completed the SIT during the observation peri...
متن کاملImportance of basophil activation testing in insect venom allergy
BACKGROUND Venom immunotherapy (VIT) is the only effective treatment for prevention of serious allergic reactions to bee and wasp stings in sensitized individuals. However, there are still many questions and controversies regarding immunotherapy, like selection of the appropriate allergen, safety and long term efficacy. METHODS Literature review was performed to address the role of basophil a...
متن کاملBasophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.
BACKGROUND Immunotherapy inhibits basophil histamine release, but the assay is cumbersome, and no one has studied the effects of immunotherapy withdrawal. OBJECTIVE Intracellular fluorochrome-labeled diamine oxidase (DAO) was used as a novel functional readout of basophil histamine release after immunotherapy. Results were compared with conventional basophil surface expression of activation m...
متن کاملChanges in basophil activation during immunotherapy with house dust mite and mugwort in patients with allergic rhinitis
Background The basophil activation test (BAT) is a promising tool for monitoring allergen-specific immunotherapy responses. Objective We aimed to investigate the changes in basophil activation in response to the inhalant allergens of house dust mite (HDM) and mugwort pollen during immunotherapy in patients with allergic rhinitis. Methods We enrolled patients with allergic rhinitis who were ...
متن کامل91 Efficacy of Venom Immunotherapy Given Every 3 or 4 Months. A Direct Prospective Comparison With the Conventional Regimen
relationship to proportion of regulatory T cells. Methods: Forty-five patients with history of systemic symptoms of allergy to Hymenoptera venom were included. Basophil reactivity before the treatment and after one year of allergen immunotherapy (AIT) was measured by CD63 expression, CD203c marker used for basophil identification. Cells were stimulated by aqueous solution of allergen in concent...
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ورودعنوان ژورنال:
- Polskie Archiwum Medycyny Wewnetrznej
دوره 126 7-8 شماره
صفحات -
تاریخ انتشار 2016